"Curb Your Enthusiasm" jokester Larry David took a DNA test on "Lopez Tonight" and found out the results in front of the studio audience.
George Lopez surprised David when he announced the comedian is 63% European and 37% Native American.
David asked, "What do you mean? I'm a Comanche? I'm in the Iroquoi tribe?"
Lopez responded, "You're a member of two tribes. You're Jewish and you're Native American!"
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The mmajority pre-Columbian Y chromosome lineage group of Native Americans is designated as Q and is defined by the m242 mutation. All living NAs with Q have a particular strain of Q called Q1a3 which is defined by the m346 mutation. m346 has been detected in 15% of Yemenite Jews (Shen 2004), Norwegians, Saudi Arabians, and Asian Indians. To my knowledge m346 is not found in Central Asians and the only Siberians that have m346 are the Khanty who live in the far western edge of Siberia.
I’m not suprised at all. This guy looks just like my brother in law…who is part Cuban (of pure Spanish descent) and part Native American/Honduran (mom looks like Geronimo, seriously). It looks like the same freakin’ guy.
Correction “RAN” Other People over lap Genetics with Native Americans! They were here 1st!!
Europeans can claim Larry!
Native Americans have overlapping genetics with Central Asians, East Asians also due to an extent hence, a European with “Native American” markers but no known Native American ancestors really has Central Asian markers. These markers are quite common in Eastern Europeans and Southeast Europeans. They are also evident in Middle Eastern Population. This can be due to various central asian asians from the Mongols, Turks, etc
Considering Larry David is an ashkenazi it is likely that he is actually part central asian.
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I know this is old news, but I will comment anyway.
RAN, it has NOTHING to do with “central Asian markers”. It has everything to do with inappropriate reference groups.
The thing is, that if there’s any kind of population which was not included in the establishing of “markers” they can have any kind of marker (the nucleotide pair can be any of four variations).
By their methodology, every person will test 100%. This means that for every person tested who does not belong to any of the reference groups used, that person will still test 100% in the test, but he may not even belong to any of the groupings. He will, however, test as belonging to the groups, but it will be wrong, of course.
This is a well known phenomenon for some Middle Eastern groups,d some East African groups and others, which means that their results cannot be used - only the groups who are represented by the initial data can be tested with some accuracy.
There are, in fact, no such thing as “racial markers” in genetics.
I’m a bit puzzled why there is no real uproar against these tests from geneticists, as the tests are like snake oil, they are often meaningless. There has been some talk, but not as much as there should be.
November 14, 2011