Disaster is hitting “Desperate Housewives,” and “Extra” has your first look at Sunday night’s devastating tornado that kills at least two residents and whips up hysteria on Wisteria Lane.

“Extra” has learned exclusively how the highly-anticipated episode will change the face of the ground-breaking ABC series.

“We’ve got someone who joined the cast late last year who’s going to die,” explained creator Marc Cherry. “And we have someone who’s been with the show pretty much from the beginning who dies.”

He added, “It’s become the most expensive show in ‘Desperate Housewives’ history.”