Martin Scorsese and Leonardo DiCaprio are once again teaming up on a new thriller.

The duo behind “The Departed” will film “Shutter Island,” a drama set in the 1950s that has Leo investigating the disappearance of a murderess who escaped from a mental hospital and sought shelter on the island.

It’s based on a novel by Dennis Lehane, the same man behind “Mystic River” and “Gone Baby Gone.”