Can anyone come between Jennifer Aniston and Courteney Cox Arquette?

Only one man -- and that is David Arquette.

The lovable “Friends” made it a party of three in Los Angeles Wednesday night for the premiere of David’s new horror movie, “The Tripper.”

“I’m very proud of David; he’s a creative genius, he’s really something else,” Courteney gushed.

Arquette directed and co-wrote the creepy flick, which hits theaters April 20.

While Courteney’s best friend Jennifer didn’t walk the red carpet, we spotted her at the screening.

As for that highly hyped lip-lock the best friends shared on F/X’s “Dirt,” can fans expect to see another dirty appearance anytime soon?

“You know what, I don’t know,” Cox said.